Pharmaceutical Information |
Drug Name |
Aldesleukin |
Drug ID |
BADD_D00062 |
Description |
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125. |
Indications and Usage |
For treatment of adults with metastatic renal cell carcinoma. |
Marketing Status |
Prescription |
ATC Code |
L03AC01 |
DrugBank ID |
DB00041
|
KEGG ID |
D00748
|
MeSH ID |
C082598
|
PubChem ID |
Not Available
|
TTD Drug ID |
D05PUD
|
NDC Product Code |
17089-380; 76310-022 |
Synonyms |
aldesleukin | Proleukin | BAY 50-4798 |
|
Chemical Information |
Molecular Formula |
Not Available |
CAS Registry Number |
110942-02-4 |
SMILES |
Not Available |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
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