Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aldesleukin
Drug ID BADD_D00062
Description Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Indications and Usage For treatment of adults with metastatic renal cell carcinoma.
Marketing Status Prescription
ATC Code L03AC01
DrugBank ID DB00041
KEGG ID D00748
MeSH ID C082598
PubChem ID Not Available
TTD Drug ID D05PUD
NDC Product Code 17089-380; 76310-022
Synonyms aldesleukin | Proleukin | BAY 50-4798
Chemical Information
Molecular Formula Not Available
CAS Registry Number 110942-02-4
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.001--
Coma17.02.09.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.001--
Death08.04.01.001--
Delirium19.13.02.001--
Demyelination17.16.02.001--Not Available
Depression suicidal19.15.01.004--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Duodenal ulcer07.04.02.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.001--
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Febrile neutropenia01.02.03.002; 08.05.02.004--
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.003--Not Available
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.003--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Hepatitis09.01.07.004--Not Available
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