Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acyclovir
Drug ID BADD_D00039
Description Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.[L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318]
Indications and Usage For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
Marketing Status Prescription; Discontinued
ATC Code D06BB03; J05AB01; S01AD03
DrugBank ID DB00787
KEGG ID D00222
MeSH ID D000212
PubChem ID 135398513
TTD Drug ID D0B5MP
NDC Product Code 71209-006; 61919-530; 68071-4790; 65085-0039; 68071-2501; 60505-5306; 61919-370; 0395-8097; 65162-835; 71205-209; 63187-366; 63629-2327; 68071-2526; 65162-836; 71335-0225; 60505-5307; 71335-1013; 53002-2450; 63629-7975; 68382-992; 68071-1841; 71335-1381; 68071-2287; 71335-1111; 70771-1371; 66689-342; 68071-2506; 55700-835; 66673-002; 70934-373; 68382-792; 70934-512; 67296-1193; 70518-2518; 49711-0094; 70771-1082; 51927-2994; 68788-7575; 53002-0270; 68084-108; 71335-1645; 75834-124; 42291-017; 55700-651; 43063-340; 70771-1384; 63629-2009; 68071-2299; 70518-3306; 50090-0638; 69076-146; 72241-028; 70934-828; 66673-001; 68071-2247; 0093-3630; 16714-885; 63629-7639; 49452-0001; 51079-550; 71335-0695; 50383-810; 71335-1222; 61919-003; 62991-1004; 54348-627; 17856-0083; 63629-7636; 70771-1383; 50090-5610; 70518-1332; 69452-291; 70934-908; 75834-122; 67296-1185; 51407-146; 23155-227; 50090-3902; 62332-248; 50090-0645; 69117-0039; 71335-1290; 68788-7895; 50090-3250; 68382-126; 68071-5100; 53002-0082; 71205-578; 17337-0041; 23155-485; 50090-0644; 65841-802; 60505-0042; 50268-062; 43063-589; 70934-408; 65841-829; 68071-2488; 67296-1089; 50268-061; 0472-0082; 51672-1360; 17337-0005; 72275-733; 0713-0630; 68071-2408; 70934-354; 60760-652; 71209-004; 68071-4799; 71205-056; 70954-188; 55154-7629; 59651-493; 50090-3795; 68071-2235; 52935-0015; 71209-005; 70934-313; 67296-1707; 50090-5739; 68382-125; 12711-9744; 63187-574; 68788-7760; 65977-0058; 66267-399; 69988-0027; 23155-229; 63646-300; 45802-044; 70934-557; 63187-154; 67296-1625; 69132-001; 68071-2447; 38779-0173; 43063-928; 69117-0018; 58118-0791; 70518-2496; 46014-1017; 63629-2328; 71335-0323; 71205-472; 71205-243; 68084-107; 0378-9735; 69097-656; 0591-1159; 63629-9174; 60760-606; 68071-5094; 68071-5122; 61442-112; 70934-907; 43547-499; 52423-0906; 76420-050; 68084-109; 12711-9755; 71205-371; 67296-1108; 67296-1034; 13668-515; 70771-1081; 63187-253; 55154-4332; 71403-049; 63629-1678; 70518-2117; 68071-3222; 70518-3331; 68071-4528; 70518-0427; 0187-0994; 70934-697; 51927-0192; 71205-388; 71335-0280; 50090-0637; 68071-5006; 63629-7613; 51552-0671; 0143-9657; 51407-145; 70934-532; 72241-027; 63310-2090; 71335-0319; 70934-800; 68382-791; 65841-803; 71205-053; 31722-777; 75834-123; 70934-694; 0143-9658; 61442-113; 67296-1723; 70700-107; 69452-290; 50090-0596; 68462-746; 67296-0710; 55700-539; 65015-600; 46708-248; 63629-1006; 0904-5790; 53002-0083; 43063-826; 72241-026; 68382-049; 70934-465; 67296-1300; 53002-0271; 50090-0642; 31722-778; 60429-012; 70934-511; 0187-0993; 71335-1077; 50090-0643; 0168-0825; 68071-5157; 72578-002; 68382-048; 61919-331; 55700-786; 63629-1005; 71335-1757; 54348-624; 68071-2279; 72578-082; 71335-1053; 50090-0595; 71335-0470; 50090-3254; 63187-182; 67296-1543; 53069-0120; 50090-1624; 0904-5789; 68788-7923; 0378-8712; 70934-131; 70518-2455; 71335-1284; 70934-491; 71205-391; 0378-8700; 69117-0019; 61442-114; 72189-232; 23155-228; 33342-439; 63187-192; 76003-0010; 70934-556; 70934-401
Synonyms Acyclovir | 9-((2-Hydroxyethoxy)methyl)guanine | Aciclovir | Acycloguanosine | Herpoviric | Aciclobeta | Aciclostad | Isavir | Laciken | Mapox | Maynar | Milavir | Opthavir | Supraviran | Viclovir | Vipral | Virax-Puren | Virax Puren | ViraxPuren | Virherpes | Virmen | Virolex | Virupos | Virzin | Wellcome-248U | Wellcome 248U | Wellcome248U | Zoliparin | Zovirax | Zyclir | Aciclovir Alonga | Alonga, Aciclovir | Acifur | Acipen Solutab | Solutab, Acipen | Acivir | Activir | Acyclo-V | Acyclo V | Acyclovir Sodium | Sodium, Acyclovir | Antiherpes Creme | aciclovir von ct | Avirax | Cicloferon | Clonorax | Cusiviral | Genvir | Herpetad | Herpofug | Herpotern | Aci-Sanorania | Aci Sanorania | Aciclovir-Sanorania | Aciclovir Sanorania | Acic
Chemical Information
Molecular Formula C8H11N5O3
CAS Registry Number 59277-89-3
SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Neurological symptomMyelin basic proteinP02686T547616305245
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypokalaemia14.05.03.0020.000313%
Hypotension24.06.03.0020.000782%
Immune system disorder10.02.01.001--Not Available
Influenza22.07.02.001; 11.05.03.0010.000313%Not Available
Injection site phlebitis08.02.03.011; 24.05.03.003; 12.07.03.012--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Intraocular pressure increased13.07.04.0020.000313%Not Available
Iridocyclitis06.04.03.0010.000469%Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice23.03.03.030; 01.06.04.004; 09.01.01.004--Not Available
Laboratory test abnormal13.18.01.0010.000313%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Lip dry07.06.01.003--Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Mania19.16.02.002--
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.0040.000313%Not Available
Neutrophilia01.02.01.005--Not Available
Ocular hyperaemia06.04.05.0040.000313%Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
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