Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage For the treatment of severe psoriasis in adults.
Marketing Status approved
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 17337-0003; 59981-011; 0093-1136; 0115-1752; 42291-087; 62147-0145; 0115-1751; 42794-081; 0378-7020; 71214-0698; 42291-088; 58159-058; 71052-692; 0115-1753; 17337-0004; 71214-0667; 0115-1750; 71214-0668; 71214-0669; 42291-086; 42794-080; 0093-1135; 0093-1138; 62147-0146; 76055-0001; 42794-083; 0378-7023
UNII LCH760E9T7
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutrophil count decreased13.01.06.010--
Neutrophil count increased13.01.06.011--Not Available
Neutrophilia01.02.01.0050.001250%Not Available
Night blindness06.02.10.010; 14.12.03.001--
Obesity14.03.02.009--
Oedema14.05.06.010; 08.01.07.0060.001250%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Optic neuritis10.02.01.097; 17.04.05.001; 06.04.08.002--Not Available
Osteoarthritis15.01.04.001--Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.001250%
Otitis externa04.01.02.001; 11.01.05.003--
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pain in extremity15.03.04.0100.001875%
Pain of skin23.03.03.0030.001250%
Palmar-plantar erythrodysaesthesia syndrome23.03.05.009; 17.02.07.0090.001875%
Pancreatitis07.18.01.0010.001250%
Pancreatitis acute07.18.01.0020.001250%Not Available
Pancytopenia01.03.03.003--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Paraesthesia23.03.03.094; 17.02.06.005--
Paronychia23.11.04.006; 11.02.01.054--
Pemphigoid23.03.01.004; 10.04.02.0020.001250%Not Available
Penis disorder21.12.01.001--Not Available
Peripheral ischaemia24.04.03.002--
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
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ADReCS-Target
Drug Name ADR Term Target
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