| ADR Ontology |
| ADR Term |
Huntington's disease |
| ADR ID |
BADD_A09078 |
| ADR Hierarchy |
|
| Description |
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4) [MeSH] |
| MedDRA Code |
10070668 |
| MeSH ID |
D006816; D006816; D006816
|
|
ADR Severity Grade (FAERS)
|
|
|
ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Huntington's chorea | Huntington's chorea aggravated | Huntington's disease | Huntington Disease | Huntington Chorea | Chorea, Huntington | Huntington's Disease | Chronic Progressive Hereditary Chorea (Huntington) | Huntington Chronic Progressive Hereditary Chorea | Progressive Chorea, Chronic Hereditary (Huntington) | Progressive Chorea, Hereditary, Chronic (Huntington) | Huntington's Chorea | Chorea, Huntington's | Chorea, Chronic Progressive Hereditary (Huntington) | Huntington Disease, Late Onset | Late-Onset Huntington Disease | Huntington Disease, Late-Onset | Late Onset Huntington Disease | Juvenile Huntington Disease | Juvenile-Onset Huntington Disease | Juvenile Onset Huntington Disease | Huntington Disease, Juvenile-Onset | Huntington Disease, Juvenile Onset | Huntington Disease, Juvenile | Akinetic-Rigid Variant of Huntington Disease | Akinetic Rigid Variant of Huntington Disease | Huntington Disease, Akinetic-Rigid Variant | Huntington Disease, Akinetic Rigid Variant |
|
|
| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
|
| Drugs Leading to the ADR |
|
|
