Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status Prescription
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 0054-0469; 60505-3882; 51224-426; 43598-394; 27241-177; 42291-806; 51224-425; 65977-0085; 47335-277; 31722-822; 68180-408; 70436-102; 51407-481; 42291-807; 65085-0064; 65015-831; 0054-0468; 69452-117; 69766-076; 43598-395; 42973-179; 62756-871; 31722-821; 64330-066; 68180-409; 64567-0025; 68682-421; 63827-1013; 51407-480; 69452-118; 47335-179; 68682-422; 60505-3883; 70436-101; 27241-176
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Aggression19.05.01.0010.003921%Not Available
Agitation19.06.02.001; 17.02.05.0120.014379%
Akathisia19.06.02.006; 17.01.02.0020.002614%
Amnesia19.20.01.001; 17.03.02.0010.005229%
Anger19.04.02.0010.009150%Not Available
Anxiety19.06.02.0020.036601%
Aphasia19.21.01.001; 17.02.03.0010.002614%
Arthralgia15.01.02.001--
Asphyxia12.01.08.011; 22.02.02.0010.001364%Not Available
Aspiration22.02.07.0070.001364%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.003921%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Back pain15.03.04.005--
Blister23.03.01.001; 12.01.06.0020.002614%Not Available
Blood creatine phosphokinase increased13.04.01.0010.002614%
Blood pressure increased13.14.03.005--Not Available
Blood sodium decreased13.11.01.0120.002614%Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bradykinesia17.01.02.004--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bruxism19.11.03.001; 07.01.06.0080.002614%Not Available
Cardiac failure02.05.01.0010.001364%
Cardiac failure congestive02.05.01.002--Not Available
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