Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Dementia with Lewy bodies
ADR ID BADD_A06471
ADR Hierarchy
17      Nervous system disorders
17.03      Mental impairment disorders
17.03.01      Dementia (excl Alzheimer's type)
17.03.01.004      Dementia with Lewy bodies
19      Psychiatric disorders
19.20      Dementia and amnestic conditions
19.20.02      Dementia NEC
19.20.02.003      Dementia with Lewy bodies
Description A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) [MeSH]
MedDRA Code 10067889
MeSH ID D020961
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Diffuse Lewy body disease | Dementia with Lewy bodies | Lewy Body Disease | Diffuse Lewy Body Disease | Lewy Body Dementia | Cortical Lewy Body Disease | Lewy Body Disease, Cortical | Lewy Body Type Senile Dementia | Lewy Body Disease, Diffuse | Dementia, Lewy Body
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00511Clozapine0.010235%
BADD_D00706Donepezil0.000128%
BADD_D01330Lurasidone--
BADD_D01567Nilotinib0.000208%
BADD_D01599Olanzapine0.001082%
BADD_D01888Quetiapine0.000166%
BADD_D02346Venlafaxine0.000058%
BADD_D02451Pimavanserin0.001178%
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