| ADR Ontology |
| ADR Term |
Kernicterus |
| ADR ID |
BADD_A02445 |
| ADR Hierarchy |
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| Description |
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) [MeSH] |
| MedDRA Code |
10023376 |
| MeSH ID |
D007647
|
|
ADR Severity Grade (FAERS)
|
Not Available
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ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Jaundice nuclear | Kernicterus | Kernicterus due to isoimmunization of fetus or newborn | Kernicterus of fetus or newborn not due to isoimmunization | Nuclear jaundice | Kernicterus due to isoimmunisation of foetus or newborn | Kernicterus of foetus or newborn not due to isoimmunisation | Bilirubin encephalopathy | Encephalopathy, Bilirubin | Bilirubin Encephalopathy | Bilirubin Encephalopathies | Encephalopathies, Bilirubin | Hyperbilirubinemic Encephalopathy | Encephalopathies, Hyperbilirubinemic | Hyperbilirubinemic Encephalopathies | Encephalopathy, Hyperbilirubinemic |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D00406 | Ceftriaxone sodium | - | - |
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