Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftriaxone sodium
Drug ID BADD_D00406
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D00924
MeSH ID D002443
PubChem ID 9570985
TTD Drug ID D07ACT
NDC Product Code 50090-2444; 60505-6151; 50090-0944; 0409-7338; 0409-7335; 50090-3810; 67184-1007; 67184-1006; 50090-4978; 25021-108; 70518-3099; 50090-3838; 38779-2383; 0409-7332; 0781-3209; 71205-545; 67184-1008; 0409-7334; 60505-6152; 70518-2499; 70518-0168; 68071-4682; 50090-3447; 0781-3210; 67184-1005; 0781-3206; 0338-5003; 0781-3207; 0338-5002; 70518-2301; 50090-1875; 0409-7333; 60505-6149; 0781-3208; 0409-7337; 51065-004; 50090-4689; 0409-7336; 60505-6150; 60505-6148; 66288-6100
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H16N8Na2O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-] .[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase13.03.01.031--Not Available
Alveolitis allergic22.01.01.002; 10.01.03.008--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Basophilia01.02.01.009--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Chills15.05.03.016; 08.01.09.001--
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.001--
Complications of transplanted liver12.02.09.014; 09.01.08.011--Not Available
Coombs direct test positive13.01.01.001--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Epistaxis24.07.01.005; 22.04.03.001--
Feeling hot08.01.09.009--Not Available
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