Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status Not Available
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 70370-1080; 47049-008; 70370-1060; 66406-0314; 47049-021; 70370-2040; 66406-0274; 70370-2048; 47049-009
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac failure congestive02.05.01.002--Not Available
Catatonia19.11.01.0010.003921%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Completed suicide08.04.01.010; 19.12.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.0050.031372%
Constipation07.02.02.001--
Crying08.01.03.005; 19.04.02.002; 17.02.05.013; 12.02.11.0010.009150%Not Available
Cystitis20.03.02.002; 11.01.14.0010.003921%
Death08.04.01.001--
Dehydration14.05.05.001--
Delusion19.10.01.0010.003921%
Dementia19.20.02.001; 17.03.01.0010.000682%Not Available
Depressed mood19.15.02.0010.013072%Not Available
Depression19.15.01.0010.032679%
Dermatitis allergic10.01.03.014; 23.03.04.0030.005229%Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.011764%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.095423%
Drooling17.02.05.0050.104573%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.0020.018300%
Dysarthria19.19.03.001; 17.02.08.0010.014379%
Dyskinesia17.01.02.0060.069280%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.018300%
Dyspnoea22.02.01.004; 02.01.03.002--
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