Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Niraparib
Drug ID BADD_D02486
Description Niraparib is an orally active PARP inhibitor developed by Tesaro to treat ovarian cancer. FDA approval on March 2017.
Indications and Usage Niraparib is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy
Marketing Status Not Available
ATC Code L01XK02
DrugBank ID DB11793
KEGG ID D10140
MeSH ID C545685
PubChem ID 24958200
TTD Drug ID D00BMF
NDC Product Code 71794-103; 69656-103; 61876-0723
Synonyms niraparib | 2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide | niraparib hydrochloride | Zejula | MK 4827 | MK4827 | MK-4827
Chemical Information
Molecular Formula C19H20N4O
CAS Registry Number 1038915-60-4
SMILES C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hair growth abnormal23.02.06.0060.000533%Not Available
Headache17.14.01.0010.013587%
Heart rate increased13.14.04.0020.008792%Not Available
Heart rate irregular13.14.04.0030.000533%Not Available
Hepatic neoplasm16.07.03.001; 09.04.03.0010.000799%Not Available
Hepatocellular injury09.01.07.0080.000533%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000533%
Hyperchlorhydria07.11.03.0010.000533%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.006394%
Hypertensive crisis24.08.01.0010.000533%Not Available
Hypoaesthesia17.02.06.0230.001332%Not Available
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.0010.000533%
Hypoxia22.02.02.0030.000533%
Ileus07.13.01.0010.000533%
Immune system disorder10.02.01.0010.000533%Not Available
Influenza22.07.02.001; 11.05.03.0010.001066%Not Available
Influenza like illness08.01.03.0100.000533%
Initial insomnia19.02.01.005; 17.15.03.0050.000799%Not Available
Insomnia19.02.01.002; 17.15.03.0020.015185%
Intestinal obstruction07.13.01.0020.002131%Not Available
Laboratory test abnormal13.18.01.0010.002664%Not Available
Lip dry07.06.01.0030.000533%Not Available
Liver disorder09.01.08.0010.000533%Not Available
Liver function test abnormal13.03.01.0130.000533%Not Available
Lymphadenopathy01.09.01.0020.000799%Not Available
Lymphoedema01.09.01.006; 24.09.01.0010.000533%
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