Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fingolimod
Drug ID BADD_D02464
Description Multiple sclerosis or MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.[A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010.[L12651] Fingolimod is currently being studied for the treatment of COVID-19, the disease caused by infection with the SARS-CoV-2 virus. Phase 2 clinical trials are currently underway and completion is expected in July 2020.[L12654]
Indications and Usage Fingolimod is a sphingosine 1-phosphate receptor modulator indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability.
Marketing Status Not Available
ATC Code L04AA27
DrugBank ID DB08868
KEGG ID D10001
MeSH ID D000068876
PubChem ID 107970
TTD Drug ID D07UHS
NDC Product Code 54893-0026; 65035-201
Synonyms Fingolimod Hydrochloride | 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride | FTY-720 | FTY 720 | FTY720 | Gilenya | Gilenia | Fingolimod
Chemical Information
Molecular Formula C19H33NO2
CAS Registry Number 162359-55-9
SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure systolic decreased13.14.03.0070.001158%Not Available
Blood pressure systolic increased13.14.03.0060.011580%Not Available
Blood sodium decreased13.11.01.012--Not Available
Blood sodium increased13.11.01.0130.003474%Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.002316%Not Available
Blood thyroid stimulating hormone increased13.10.03.006--
Blood triglycerides increased13.12.03.0010.014475%Not Available
Blood urea decreased13.13.01.0170.003474%Not Available
Blood urea increased13.13.01.0060.008106%Not Available
Blood uric acid decreased13.02.04.0040.001158%Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bowen's disease23.08.02.004; 16.03.02.0040.008685%Not Available
Bradycardia02.03.02.0020.171961%Not Available
Brain abscess11.01.03.003; 17.06.07.0010.002316%Not Available
Brain herniation17.11.01.002; 12.01.10.001--Not Available
Breast abscess18.06.02.002; 21.05.03.003; 11.01.02.0020.001737%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.103061%Not Available
Breast cancer stage IV21.05.01.010; 16.10.01.0030.001158%Not Available
Breast cyst21.05.01.006; 16.14.01.0040.002895%Not Available
Breast discharge21.05.05.0010.001737%Not Available
Breast mass21.05.04.0020.016212%Not Available
Breast neoplasm21.05.01.004; 16.10.02.0010.003474%Not Available
Breast pain21.05.05.003--
Breath odour07.01.06.0020.001737%Not Available
Breech presentation18.03.04.0010.001737%Not Available
Bronchiolitis22.03.02.004; 11.05.04.0080.001737%Not Available
Bronchitis11.01.09.001; 22.07.01.0010.066584%
Bronchitis chronic22.03.01.0190.002895%Not Available
The 6th Page    First    Pre   6 7 8 9 10    Next   Last    Total 63 Pages