Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lanreotide
Drug ID BADD_D02461
Description Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured by the company, _Ipsen Pharmaceuticals_ as lanreotide acetate, and marketed as _Somatuline_. It is approved in several countries worldwide, including the United Kingdom, Australia, and Canada. Lanreotide was first approved for use in the United States by the FDA on August 30, 2007.
Indications and Usage Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2)
Marketing Status Not Available
ATC Code H01CB03
DrugBank ID DB06791
KEGG ID D04666
MeSH ID C060347
PubChem ID 6918011
TTD Drug ID D0M2YE
NDC Product Code 52416-117
Synonyms lanreotide | 3-(2-naphthyl)alanyl-cystinyl-tyrosyl-tryptophyl-lysyl-valyl-cystinyl-threonine amide | D-Nal-Cys-Tyr-Trp-Lys-Val-Cys-Thr-NH2 | angiopeptin | naphthalenyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)threoninamide | L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)-Thr-NH2 | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide | 3-(2-naphthyl)-D-Ala-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 | naphthyl-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | BIM 23014 | BIM-23014 | DC 13-116 | DC13-116 | DC-13-116 | lanreotide acetate | Somatulina | Somatuline | lanreotide-SR | BIM 23014 C | BIM 23014C | BIM-23014 C | 188Re-lanreotide | Somatulin
Chemical Information
Molecular Formula C54H69N11O10S2
CAS Registry Number 108736-35-2
SMILES CC(C)C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC 4=CC=C(C=C4)O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)N)C(=O)NC(C(C)O)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disorientation19.13.01.002; 17.02.05.0150.003921%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.041166%
Dysarthria19.19.03.001; 17.02.08.0010.003921%
Dyspepsia07.01.02.0010.005881%
Dyspnoea22.02.01.004; 02.01.03.0020.025483%
Eructation07.01.02.0030.003921%
Eye pain06.08.03.0020.003921%
Faeces discoloured07.01.03.0020.003921%Not Available
Fatigue08.01.01.0020.070570%
Feeling abnormal08.01.09.0140.007841%Not Available
Feeling cold08.01.09.0080.003921%Not Available
Flatulence07.01.04.0020.029404%
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.011762%
Frequent bowel movements07.02.04.0020.003921%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gastrooesophageal reflux disease07.02.02.0030.005881%
Gastrointestinal disorder07.11.01.0010.009801%Not Available
Gastrointestinal pain07.01.05.0050.003921%
Haematocrit decreased13.01.05.0010.003921%Not Available
Haemoglobin decreased13.01.05.0030.005881%Not Available
Headache17.14.01.0010.064689%
Heart rate decreased13.14.04.0010.009801%Not Available
Heart rate increased13.14.04.0020.005881%Not Available
Hepatic failure09.01.03.0020.001023%
Hyperglycaemia05.06.02.002; 14.06.02.0020.003921%
Hyperhidrosis23.02.03.004; 08.01.03.0280.015682%
Hyperkalaemia14.05.03.0010.003921%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.013722%
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