Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium
Drug ID BADD_D02443
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Used in the management of chronic obstructive pulmonary disease (COPD).
Marketing Status Not Available
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487427
TTD Drug ID D0P1WA
NDC Product Code Not Available
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22NO4S2+
CAS Registry Number 186691-13-4
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia19.19.03.002; 17.02.08.004; 22.02.05.0050.004137%
Dyspnoea22.02.01.004; 02.01.03.0020.045024%
Dyspnoea exertional22.02.01.005; 02.01.03.0030.001582%Not Available
Dysuria20.02.02.0020.001825%
Eating disorder19.09.01.008; 14.03.01.008--Not Available
Eczema23.03.04.0060.000243%
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram ST segment depression13.14.05.0050.000243%Not Available
Emphysema22.01.02.0020.000571%Not Available
Eosinophilia01.02.04.0010.000608%
Epistaxis24.07.01.005; 22.04.03.0010.001339%
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.0010.000365%Not Available
Eye pain06.08.03.0020.000973%
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.000365%Not Available
Feeling jittery08.01.09.0160.000973%Not Available
Femoral neck fracture15.08.03.002; 12.04.01.0020.000095%Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Flatulence07.01.04.0020.000608%
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Forced expiratory volume decreased13.19.01.0030.000365%
Fracture15.08.02.001; 12.04.02.0010.001339%
Fungal infection11.03.05.001--Not Available
Gait disturbance08.01.02.002; 17.02.05.016--
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