Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status Not Available
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 51407-297; 43598-368; 42291-461; 72865-152; 50268-153; 47335-379; 42291-459; 65162-213; 16714-079; 31722-104; 63629-8763; 42291-460; 64380-885; 67877-505; 68180-227; 68180-228; 72865-151; 65162-155; 16729-440; 63629-8765; 43598-367; 31722-103; 16714-080; 31722-105; 16729-441; 69097-410; 60687-525; 69097-412; 16714-078; 65862-831; 72865-150; 65862-833; 47335-380; 69097-411; 47335-600; 76282-676; 51407-296; 42543-961; 0904-7067; 65862-832; 76282-674; 64380-883; 64380-884; 42543-962; 43598-369; 51407-295; 67877-503; 67877-504; 42543-963; 68180-226; 76282-675; 65162-157; 63629-8764; 16729-442
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysuria20.02.02.002--
Ear infection11.01.05.001; 04.03.01.006--Not Available
Eating disorder19.09.01.008; 14.03.01.0080.016125%Not Available
Eczema23.03.04.006--
Electrocardiogram QT prolonged13.14.05.004--
Electrolyte imbalance14.05.01.002--Not Available
Encephalopathy17.13.02.001--
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.006271%
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001--Not Available
Eye swelling06.08.03.003--Not Available
Facial paralysis17.04.03.008--Not Available
Faeces discoloured07.01.03.0020.017917%Not Available
Faeces hard07.01.03.0030.001792%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.008--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.016--Not Available
Fistula15.03.02.0010.008958%Not Available
Flatulence07.01.04.002--
Fluid overload14.05.06.001; 02.05.04.0040.009854%Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Foot fracture12.04.01.012; 15.08.03.012--Not Available
Formication19.10.02.010; 17.02.06.0180.004479%Not Available
Fracture15.08.02.001; 12.04.02.001--
Frequent bowel movements07.02.04.002--Not Available
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