Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status approved
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 72865-150; 72865-151; 72865-152; 42291-459; 65862-832; 16714-080; 42291-461; 67877-504; 68180-228; 42543-962; 47335-600; 51407-297; 63629-8765; 63629-8764; 63629-9607; 64380-885; 67877-503; 69097-410; 69097-412; 47335-380; 50268-153; 51407-296; 76282-674; 76282-675; 16729-440; 16729-441; 31722-104; 65162-155; 65162-213; 67877-505; 42291-460; 42543-961; 43598-368; 65162-157; 65862-831; 69097-411; 43598-369; 63629-8763; 63629-9606; 63629-9608; 65862-833; 68180-226; 31722-103; 47335-379; 60687-525; 64380-883; 68180-227; 76282-676; 0904-7067; 31722-105; 43598-367; 64380-884; 16729-442; 42543-963; 51407-295
UNII UAZ6V7728S
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.265427%Not Available
Abdominal pain upper07.01.05.0030.177121%
Abdominal rigidity07.01.05.0110.001329%Not Available
Abnormal sensation in eye06.01.01.0010.000860%Not Available
Aortic dissection24.02.03.0020.000391%Not Available
Arrhythmia02.03.02.0010.028654%Not Available
Azotaemia20.01.01.0010.000391%Not Available
Back disorder15.03.05.0030.004183%Not Available
Bone pain15.02.01.0010.019311%
Cachexia14.03.02.001; 08.01.01.009; 16.32.03.0110.000586%Not Available
Calcinosis08.03.04.0020.000977%Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.0090.003362%Not Available
Carpal tunnel syndrome17.09.02.0010.001525%Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.0060.000391%Not Available
Constipation07.02.02.0010.106249%
Death08.04.01.0010.173759%
Defaecation urgency07.02.04.0010.001329%Not Available
Diabetic neuropathy05.07.04.003; 17.09.04.002; 14.07.04.0030.000860%Not Available
Diarrhoea07.02.01.0010.351818%
Duodenitis07.08.03.0010.000391%Not Available
Dyspepsia07.01.02.0010.032602%
Dysphagia07.01.06.0030.064226%
Eating disorder19.09.01.008; 14.03.01.0080.011024%Not Available
Eructation07.01.02.0030.003714%
Faeces discoloured07.01.03.0020.011415%Not Available
Faeces hard07.01.03.0030.001329%Not Available
Fistula15.03.02.0010.003831%Not Available
Flatulence07.01.04.0020.013682%
Food allergy10.01.01.0120.000860%Not Available
Formication19.10.04.002; 17.02.06.0180.003323%Not Available
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