Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibandronate
Drug ID BADD_D02426
Description Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Indications and Usage For the treatment and prevention of osteoporosis in postmenopausal women.
Marketing Status Not Available
ATC Code M05BA06
DrugBank ID DB00710
KEGG ID D04486
MeSH ID D000077557
PubChem ID 60852
TTD Drug ID D08SJZ
NDC Product Code Not Available
Synonyms Ibandronic Acid | Ibandronate | 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate | (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate | Ibandronate Sodium Anhydrous | Boniva | Bonviva | Ibandronate Sodium | Ibandronic Acid, Sodium Salt, Monohydrate | RPR 102289A | RPR-102289A | RPR102289A | Bondronat | BM 21.0955 | BM 210955 | BM-21.0955 | BM21.0955 | BM-210955 | BM210955
Chemical Information
Molecular Formula C9H23NO7P2
CAS Registry Number 114084-78-5
SMILES CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.005694%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.0230.005694%Not Available
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.0100.030603%
Insomnia19.02.01.002; 17.15.03.002--
Joint swelling15.01.02.0040.005694%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.001423%Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Mass08.03.05.0030.002135%Not Available
Memory impairment19.20.01.003; 17.03.02.003--
Migraine24.03.05.003; 17.14.02.0010.002847%Not Available
Mouth ulceration07.05.06.0040.001423%Not Available
Movement disorder17.01.02.0100.002135%Not Available
Muscle disorder15.05.03.0140.001423%Not Available
Muscle spasms15.05.03.0040.016369%
Muscular weakness15.05.06.001; 17.05.03.0050.003559%
Musculoskeletal pain15.03.04.0070.019928%
Myalgia15.05.02.0010.046261%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.0010.034873%
Neck pain15.03.04.0090.005694%
Necrosis24.04.02.006; 08.03.03.0010.002135%Not Available
Nephrolithiasis20.04.01.0020.002847%
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