Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibandronate
Drug ID BADD_D02426
Description Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Indications and Usage For the treatment and prevention of osteoporosis in postmenopausal women.
Marketing Status Not Available
ATC Code M05BA06
DrugBank ID DB00710
KEGG ID D04486
MeSH ID D000077557
PubChem ID 60852
TTD Drug ID D08SJZ
NDC Product Code Not Available
Synonyms Ibandronic Acid | Ibandronate | 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate | (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate | Ibandronate Sodium Anhydrous | Boniva | Bonviva | Ibandronate Sodium | Ibandronic Acid, Sodium Salt, Monohydrate | RPR 102289A | RPR-102289A | RPR102289A | Bondronat | BM 21.0955 | BM 210955 | BM-21.0955 | BM21.0955 | BM-210955 | BM210955
Chemical Information
Molecular Formula C9H23NO7P2
CAS Registry Number 114084-78-5
SMILES CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Exostosis15.02.04.0050.001423%
Extravasation08.01.03.0080.024198%Not Available
Facial pain08.01.08.0120.002135%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Femoral neck fracture15.08.03.002; 12.04.01.0020.007117%Not Available
Femur fracture15.08.03.003; 12.04.01.0030.064765%Not Available
Flatulence07.01.04.0020.004982%
Fluid retention20.01.02.003; 14.05.06.0020.002135%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Foot fracture15.08.03.012; 12.04.01.0120.003559%Not Available
Fracture15.08.02.001; 12.04.02.0010.007117%
Gait disturbance08.01.02.002; 17.02.05.016--
Gastritis07.08.02.0010.004270%
Gastrooesophageal reflux disease07.02.02.0030.007117%
Gastrointestinal disorder07.11.01.0010.006405%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.0050.001423%
Gingival bleeding24.07.02.010; 07.09.07.0010.001423%Not Available
Gingivitis11.01.04.013; 07.09.03.0030.003559%
Glomerular filtration rate decreased13.13.01.0090.002847%Not Available
Haematoma24.07.01.001--
Haemorrhoids24.10.02.002; 07.15.03.0010.001423%
Hair texture abnormal23.02.06.0040.001423%
Headache17.14.01.001--
Hernia08.01.04.0010.002135%Not Available
Hip fracture12.04.01.001; 15.08.03.0010.014946%
Humerus fracture15.08.03.008; 12.04.01.0090.001423%Not Available
Hypercalcaemia05.04.01.002; 14.04.01.0030.002135%
Hyperglycaemia14.06.02.002; 05.06.02.0020.001423%
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