ADReCS

Pharmaceutical Information

Drug Name	Foscarnet
Drug ID	BADD_D02421
Description	An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Indications and Usage	For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Marketing Status	approved
ATC Code	J05AD01
DrugBank ID	DB00529
KEGG ID	D00579; D02267
MeSH ID	D017245
PubChem ID	3415
TTD Drug ID	D0OT0O
NDC Product Code	Not Available
UNII	364P9RVW4X
Synonyms	Foscarnet \| Phosphonoformic Acid \| Foscarnet Trisodium Salt \| Foscarnet Calcium (2:3) Salt \| Foscarnet Disodium Salt \| Foscarnet Magnesium (2:3) Salt \| Trisodium Phosphonoformate \| Phosphonoformate \| Foscarnet Sodium \| Foscarnet Trilithium Salt \| Foscarnet Tripotassium Salt \| Foscarnet Sodium Hexahydrate \| Foscavir \| Foscarnet Barium (2:3) Salt \| Foscarnet Manganese (2+) (2:3) Salt

Chemical Information

Molecular Formula	CH3O5P
CAS Registry Number	4428-95-9
SMILES	C(=O)(O)P(=O)(O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal pain	07.01.05.002	0.000621%
Acute respiratory distress syndrome	24.03.02.034; 10.02.01.067; 22.01.03.001	0.000423%
Altered state of consciousness	19.07.01.003; 17.02.04.001	0.000423%		Not Available
Cardiac arrest	02.03.04.001	0.000282%
Cardiac failure	02.05.01.001	0.000282%
Condition aggravated	08.01.03.004	0.000565%		Not Available
Cystitis haemorrhagic	20.03.02.003	0.000282%		Not Available
Dermatomyositis	10.04.04.027; 23.03.02.001; 15.05.01.002	0.000282%		Not Available
Disseminated intravascular coagulation	01.01.02.002; 24.01.01.010	0.000282%
Drug ineffective	08.06.01.006	0.001609%		Not Available
Dysuria	20.02.02.002	0.000282%
Electrolyte imbalance	14.05.01.002	0.000282%		Not Available
Gastrointestinal haemorrhage	24.07.02.009; 07.12.02.001	0.000282%		Not Available
Haematuria	21.10.01.018; 20.02.01.006; 24.07.01.047	0.000282%
Headache	17.14.01.001	0.000423%
Hepatic encephalopathy	17.13.01.003; 09.01.03.006	0.000282%		Not Available
Hepatic failure	09.01.03.002	0.000706%
Hypocalcaemia	14.04.01.004	0.001129%
Hypokalaemia	14.05.03.002	0.001270%
Hypomagnesaemia	14.04.02.001	0.000565%
Hypophosphataemia	14.04.03.001	0.000423%
Interstitial lung disease	22.01.02.003; 10.02.01.033	0.000282%		Not Available
Nephropathy toxic	20.05.03.002; 12.03.01.010	0.000282%		Not Available
Neuropathy peripheral	17.09.03.003	0.000423%		Not Available
Pancreatitis	07.18.01.001	0.000282%
Pancytopenia	01.03.03.003	0.000706%		Not Available
Paraesthesia	23.03.03.094; 17.02.06.005	0.000423%
Polyneuropathy	17.09.03.012	0.000282%		Not Available
Pulmonary oedema	22.01.03.003; 02.05.02.003	0.000282%
Pyrexia	08.05.02.003	0.000282%

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