Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rosiglitazone
Drug ID BADD_D02419
Description Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
Indications and Usage Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Not Available
ATC Code A10BG02
DrugBank ID DB00412
KEGG ID D08491
MeSH ID D000077154
PubChem ID 77999
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Rosiglitazone | Rosiglitazone Maleate | 5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate | Avandia | BRL 49653 | BRL-49653 | BRL49653
Chemical Information
Molecular Formula C18H19N3O3S
CAS Registry Number 122320-73-4
SMILES CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dementia17.03.01.001; 19.20.02.001--Not Available
Dementia Alzheimer's type19.20.03.001; 17.03.06.001--Not Available
Depression19.15.01.001--
Diabetes mellitus14.06.01.001; 05.06.01.0010.004906%Not Available
Diabetes mellitus inadequate control14.06.01.004; 05.06.01.0040.000801%Not Available
Diabetic coma17.02.09.004; 14.07.04.002; 05.07.04.0020.000052%Not Available
Diabetic neuropathy05.07.04.003; 17.09.04.002; 14.07.04.0030.000300%Not Available
Diabetic retinal oedema14.07.01.001; 06.04.06.001; 05.07.01.0010.000200%Not Available
Diabetic retinopathy14.07.01.002; 06.10.02.002; 05.07.01.002; 24.03.07.0040.001302%Not Available
Diarrhoea07.02.01.001--
Dilatation atrial02.04.02.0190.000200%Not Available
Dilatation ventricular02.04.02.026--Not Available
Diplegia17.01.04.0150.000200%Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Dysarthria19.19.03.001; 17.02.08.001--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dyspnoea exertional22.02.01.005; 02.01.03.003--Not Available
Dysuria20.02.02.002--
Eating disorder19.09.01.008; 14.03.01.008--Not Available
Electrocardiogram abnormal13.14.05.0010.003504%Not Available
Electrocardiogram ST segment elevation13.14.05.0250.000400%Not Available
Embolic stroke17.08.01.032; 24.01.04.0100.001702%Not Available
Emotional disorder19.04.02.005--Not Available
Encephalopathy17.13.02.001--
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