Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine
Drug ID BADD_D02416
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Not Available
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D08490
MeSH ID D000077212
PubChem ID 175805
TTD Drug ID D09RHQ
NDC Product Code 76339-126; 29902-0022
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H26N2O
CAS Registry Number 84057-95-4
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness17.05.03.005; 15.05.06.0010.001970%
Neurotoxicity17.02.10.002; 12.03.01.0110.000788%Not Available
Pain08.01.08.0040.002364%
Paralysis17.01.04.0040.000788%Not Available
Paresis17.01.04.0080.001182%Not Available
Respiratory arrest22.02.01.0090.000206%Not Available
Respiratory distress22.02.01.0120.001182%Not Available
Seizure17.12.03.0010.003547%
Sinus tachycardia02.03.03.0100.000788%
Stridor22.04.02.0030.000788%
Tachycardia02.03.02.0070.001576%Not Available
Tremor17.01.06.0020.001576%
Visual impairment06.02.06.0080.000788%Not Available
Nerve injury17.02.10.007; 12.01.12.0020.000788%Not Available
Haemorrhage24.07.01.0020.000206%Not Available
Procedural pain08.01.08.009; 12.02.05.0070.002759%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000788%Not Available
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