Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine
Drug ID BADD_D02416
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Not Available
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D08490
MeSH ID D000077212
PubChem ID 175805
TTD Drug ID D09RHQ
NDC Product Code 76339-126; 29902-0022
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H26N2O
CAS Registry Number 84057-95-4
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.0020.000206%Not Available
Anxiety19.06.02.0020.000788%
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.0090.000788%
Apnoea22.02.01.0010.000206%
Arthropathy15.01.01.0030.007093%Not Available
Atrial tachycardia02.03.03.0040.000788%
Blindness17.17.01.003; 06.02.02.0010.000788%Not Available
Blood pressure increased13.14.03.0050.001182%Not Available
Bradycardia02.03.02.0020.001576%Not Available
Cardiac arrest02.03.04.0010.000925%
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.000788%Not Available
Circulatory collapse24.06.02.0010.000206%Not Available
Coma17.02.09.0010.000206%Not Available
Death08.04.01.001--
Delayed recovery from anaesthesia17.02.04.011; 12.02.12.0030.000788%Not Available
Diaphragmatic paralysis22.09.02.002; 17.01.04.0140.000788%Not Available
Diplegia17.01.04.0150.000788%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001182%
Dysgeusia07.14.03.001; 17.02.07.0030.001182%
Dyskinesia17.01.02.0060.002364%
Dysphoria19.04.02.0040.000788%Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.002759%
Generalised tonic-clonic seizure17.12.01.0020.001970%Not Available
Headache17.14.01.0010.001970%
Heart rate abnormal13.14.04.0060.000788%Not Available
Horner's syndrome16.32.03.006; 06.09.04.002; 17.05.01.0040.000788%Not Available
Hypoaesthesia17.02.06.0230.009458%Not Available
Hypotension24.06.03.0020.001576%
Loss of consciousness17.02.04.0040.001576%Not Available
Movement disorder17.01.02.0100.006699%Not Available
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