Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Zolmitriptan
Drug ID BADD_D02393
Description Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)1B/1D/(1F) receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptans, including [almotriptan], [eletriptan], [frovatriptan], [naratriptan], [rizatriptan], and zolmitriptan.[A193791] Triptans can be administered alone or in combination with an NSAID like [naproxen], and represent the current "gold standard" for acute migraine treatment.[A193797] Zolmitriptan was first approved by the FDA for sale by Zeneca Pharmaceuticals under the trade name Zomig® on November 25, 1997. It is currently available in both tablet and nasal spray forms.[L12978]
Indications and Usage For the acute treatment of adult migraine with or without auras.
Marketing Status Prescription; Discontinued
ATC Code N02CC03
DrugBank ID DB00315
KEGG ID D00415
MeSH ID C089750
PubChem ID 60857
TTD Drug ID D0NG7O
NDC Product Code 69097-863; 68382-715; 69097-864; 64896-671; 54864-955; 64896-681; 65862-915; 64896-691; 68462-497; 68382-717; 64980-203; 11722-012; 59746-462; 50742-625; 55700-944; 46708-182; 55111-800; 63548-0101; 59746-433; 64896-672; 46708-181; 65862-914; 63850-4322; 63548-0102; 68001-250; 55700-943; 16571-804; 65841-768; 68382-712; 27241-022; 45802-711; 16571-803; 46708-462; 46708-463; 68001-249; 59746-461; 64980-257; 65862-801; 67835-5007; 64896-692; 64896-682; 65977-0050; 65841-766; 69238-2006; 68462-500; 71626-102; 64980-204; 71626-101; 50742-626; 65841-767; 68462-498; 65841-765; 72606-568; 64980-256; 68382-714; 72606-567; 68462-499; 65015-688; 69238-2007; 59746-432; 66039-845; 64567-0016; 46708-898; 65372-1145; 27241-021
Synonyms zolmitriptan | 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone | Zomig | AscoTop | Zomigoro | 311C90 | Flezol
Chemical Information
Molecular Formula C16H21N3O2
CAS Registry Number 139264-17-8
SMILES CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal carcinoma16.13.04.001; 07.21.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gingivitis07.09.03.003; 11.01.04.013--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Hair disorder23.02.06.003--Not Available
Hallucination19.10.02.002--
Headache17.14.01.0010.020168%
Hepatic neoplasm16.07.03.001; 09.04.03.001--Not Available
Hepatocellular injury09.01.07.0080.003103%Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.0280.007757%
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperthyroidism14.11.01.011; 05.02.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypotonia17.05.02.002; 15.05.04.008--Not Available
Immune system disorder10.02.01.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.0020.009308%
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