Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
Marketing Status Prescription
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0904-6596; 0049-3180; 40032-089; 70966-0030; 65841-831; 43547-378; 0049-4190; 0904-6471; 0781-5668; 0395-8230; 27241-062; 72266-131; 68462-573; 70710-1247; 51552-1524; 0378-1640; 60715-1700; 0781-5667; 40032-038; 65862-891; 60687-294; 43547-377; 43386-088; 51407-133; 53296-0081; 63629-8734; 43386-089; 0049-3170; 65862-916; 65841-830; 66039-951; 60687-273; 59762-0935; 70771-1413; 0049-3190; 58032-2007; 0378-1626; 14501-0014; 63739-008; 68462-572; 16436-0081; 72969-077; 51079-165; 27241-063; 64980-274; 65015-801; 51552-1573; 52562-001; 72578-063; 0904-7024; 65862-892; 63126-911; 65219-190; 72578-062; 0781-3416; 70436-029; 64220-140; 59762-0936; 16714-199; 68083-321; 65372-1175; 51079-164; 59762-0934; 43386-038; 64980-275; 66039-876; 39822-1077; 0049-3160; 68554-0111; 40032-088; 71052-149; 65162-913; 47781-466; 73223-005; 16714-198; 55111-099
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Exophthalmos06.09.04.001; 05.02.02.0020.039934%Not Available
Exostosis15.02.04.0050.066556%
Extrapyramidal disorder17.01.02.007--
Extrasystoles02.03.02.003--Not Available
Eye disorder06.08.03.0010.093178%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001--Not Available
Eye pain06.08.03.0020.039934%
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.066556%
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.226290%
Feeling abnormal08.01.09.014--Not Available
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.017--Not Available
Flank pain08.01.08.007; 20.02.03.006; 15.03.04.003--
Flatulence07.01.04.002--
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Fluoride increased13.17.02.0070.173045%Not Available
Fluorosis12.03.01.023--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Fungaemia11.01.11.0020.006945%
Fungal infection11.03.05.0010.118064%Not Available
Furuncle23.09.01.004; 11.02.05.008--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.252912%
Gastric ulcer07.04.03.002--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.002--Not Available
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