Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
Marketing Status Prescription
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0904-6596; 0049-3180; 40032-089; 70966-0030; 65841-831; 43547-378; 0049-4190; 0904-6471; 0781-5668; 0395-8230; 27241-062; 72266-131; 68462-573; 70710-1247; 51552-1524; 0378-1640; 60715-1700; 0781-5667; 40032-038; 65862-891; 60687-294; 43547-377; 43386-088; 51407-133; 53296-0081; 63629-8734; 43386-089; 0049-3170; 65862-916; 65841-830; 66039-951; 60687-273; 59762-0935; 70771-1413; 0049-3190; 58032-2007; 0378-1626; 14501-0014; 63739-008; 68462-572; 16436-0081; 72969-077; 51079-165; 27241-063; 64980-274; 65015-801; 51552-1573; 52562-001; 72578-063; 0904-7024; 65862-892; 63126-911; 65219-190; 72578-062; 0781-3416; 70436-029; 64220-140; 59762-0936; 16714-199; 68083-321; 65372-1175; 51079-164; 59762-0934; 43386-038; 64980-275; 66039-876; 39822-1077; 0049-3160; 68554-0111; 40032-088; 71052-149; 65162-913; 47781-466; 73223-005; 16714-198; 55111-099
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cheilitis23.03.03.025; 07.05.01.0010.106489%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Chloropsia06.02.05.0040.039934%Not Available
Cholecystitis09.03.01.001--
Cholecystitis acute09.03.01.0030.026622%Not Available
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.0010.306157%Not Available
Chromatopsia06.02.05.0010.319468%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.020835%Not Available
Colour blindness06.02.09.001; 03.01.01.001--Not Available
Colour blindness acquired06.02.09.002--Not Available
Coma17.02.09.001--Not Available
Coma hepatic09.01.03.005; 17.02.09.002--Not Available
Confusional state19.13.01.001; 17.02.03.0050.412647%
Conjunctivitis11.01.06.012; 06.04.01.0020.039934%
Constipation07.02.02.001--
Conversion disorder19.24.01.0010.026622%Not Available
Coordination abnormal17.02.02.0040.053245%Not Available
Corneal opacity06.06.03.005--Not Available
Corneal perforation12.01.04.003; 06.06.03.0060.026622%Not Available
Cough22.02.03.001--
Creatinine renal clearance increased13.13.01.0150.006945%Not Available
Creatinine renal clearance decreased13.13.01.013--Not Available
Cryptococcosis11.03.04.0010.010417%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Cystitis haemorrhagic20.03.02.003--Not Available
Cytomegalovirus infection11.05.01.0020.026622%
Deafness04.02.01.0010.066556%Not Available
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