Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.[L9821, L15571]
Marketing Status approved
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0781-5667; 60715-1700; 65372-1175; 27241-063; 39822-1077; 43386-088; 0378-1640; 66039-951; 70966-0030; 47781-466; 0049-4190; 55111-099; 58032-2007; 66039-876; 43386-038; 51079-164; 0049-3190; 64980-274; 64980-275; 65862-891; 68462-572; 70594-067; 70710-1247; 60687-273; 0378-1626; 65841-830; 72572-875; 68554-0111; 75945-102; 16714-199; 43547-378; 59762-0936; 63739-008; 65162-913; 65841-831; 0904-6596; 65862-916; 71052-149; 40032-038; 43386-089; 50268-803; 0049-3180; 68083-321; 71288-027; 72578-062; 14501-0014; 52562-001; 27241-062; 43547-377; 51552-1524; 16714-198; 59762-0934; 60687-294; 65219-190; 65862-892; 70771-1413; 72843-441; 0781-5668; 63126-911; 0049-3170; 70436-029; 72578-063; 0781-3416; 0904-7024; 51552-1573; 53296-0081; 64220-140; 65015-801; 73223-005; 51079-165; 63629-8734; 0049-3160; 68462-573; 72266-131; 51407-133; 55150-321; 59762-0935
UNII JFU09I87TR
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Melanosis23.05.01.004--Not Available
Metastases to liver16.22.02.001; 09.04.02.0040.014521%Not Available
Microcytic anaemia01.03.02.008--Not Available
Microcytosis01.07.02.005--Not Available
Mouth ulceration07.05.06.0040.015683%Not Available
Mucosal ulceration08.01.06.0030.014521%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.228856%
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.0010.005809%
Mydriasis06.05.03.004; 17.02.11.003--Not Available
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.014521%
Myocardial infarction24.04.04.009; 02.02.02.007--
Myoclonus17.02.05.0080.008713%Not Available
Myopathy15.05.05.001--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.0010.017426%Not Available
Neoplasm malignant16.16.01.0010.043564%Not Available
Nephritis20.05.02.001--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.014521%Not Available
Nephrotic syndrome20.05.01.0020.008713%
Nervous system disorder17.02.10.0010.047630%Not Available
Neuralgia17.02.07.0050.035432%
Neuroendocrine carcinoma of the skin05.08.01.009; 23.08.02.008; 16.03.02.0080.034851%Not Available
Neuropathy peripheral17.09.03.0030.066798%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.156830%Not Available
Night blindness14.12.03.001; 06.02.10.010--
Nightmare19.02.03.0030.037175%Not Available
Nodal arrhythmia02.03.03.020--Not Available
Nodal rhythm02.03.03.021--Not Available
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