Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vismodegib
Drug ID BADD_D02365
Description Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.
Indications and Usage Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.
Marketing Status Prescription
ATC Code L01XJ01
DrugBank ID DB08828
KEGG ID D09992
MeSH ID C538724
PubChem ID 24776445
TTD Drug ID D03EDQ
NDC Product Code 50242-140
Synonyms HhAntag691 | NSC 747691 | NSC747691 | NSC-747691 | R 3616 | R3616 cpd | R-3616 | vismodegib | erivedge | GDC 0449 | GDC0449 | GDC-0449 | RG 3616 | RG3616 | RG-3616
Chemical Information
Molecular Formula C19H14Cl2N2O3S
CAS Registry Number 879085-55-9
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute kidney injury20.01.03.016--
Craniocerebral injury17.11.01.007; 12.01.10.0120.000533%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.023--Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.021--Not Available
Diffuse alopecia23.02.02.0070.000533%Not Available
Multiple organ dysfunction syndrome08.01.03.057--
Myeloproliferative neoplasm16.21.03.006; 01.13.03.0060.000139%Not Available
Liver function test increased13.03.01.0440.003730%Not Available
Ruptured cerebral aneurysm24.02.04.005; 17.08.01.0590.000139%Not Available
Poor dental condition07.09.05.0140.000533%Not Available
Metastatic squamous cell carcinoma16.16.01.0100.000139%Not Available
Trichodysplasia spinulosa23.03.08.015; 10.03.02.0040.000533%Not Available
Invasive ductal breast carcinoma16.10.01.013; 21.05.01.0210.000533%Not Available
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