Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine
Drug ID BADD_D02360
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D08679
MeSH ID D014750
PubChem ID 5978
TTD Drug ID D09QVV
NDC Product Code Not Available
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10
CAS Registry Number 57-22-7
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukaemia16.01.03.001; 01.10.03.001--
Leukopenia01.02.02.0010.000533%Not Available
Malaise08.01.01.003--
Menorrhagia21.01.03.002--
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.0020.001865%Not Available
Muscle atrophy17.05.03.004; 15.05.03.003--Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.000799%
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myelodysplastic syndrome01.10.04.001; 16.01.04.0010.000139%
Myocardial infarction24.04.04.009; 02.02.02.007--
Myoclonus17.02.05.008--Not Available
Myopathy15.05.05.0010.000533%Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.0010.000799%Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.0030.007726%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.001332%Not Available
Neutropenia01.02.03.0040.002398%Not Available
Neutrophil count decreased13.01.06.0100.000533%
Nystagmus17.02.02.006; 06.05.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.000533%
Optic atrophy06.09.02.001--Not Available
Oxygen saturation decreased13.02.01.0040.000533%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.0030.000533%Not Available
Pancytopenia01.03.03.0030.001598%Not Available
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