Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vinblastine sulfate
Drug ID BADD_D02359
Description Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Indications and Usage For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Marketing Status Prescription; Discontinued
ATC Code L01CA01
DrugBank ID DB00570
KEGG ID D01068
MeSH ID D014747
PubChem ID 5388983
TTD Drug ID D0W9MM
NDC Product Code 53104-7504; 72969-083; 48954-588; 63323-278
Synonyms Vinblastine | Vincaleukoblastine | Lemblastine | Velban | Vinblastina Lilly | Velbe | Vinblastine Sulfate | Sulfate, Vinblastine | Vinblastinsulfat-Gry | Cellblastin | Vinblastin Hexal
Chemical Information
Molecular Formula C46H58N4O9.H2O4S
CAS Registry Number 143-67-9
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Asthenia08.01.01.001--Not Available
Bone pain15.02.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Constipation07.02.02.001--
Deafness04.02.01.001--Not Available
Depilation25.12.01.002--Not Available
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Electrocardiogram abnormal13.14.05.001--Not Available
Enterocolitis haemorrhagic07.08.01.007; 24.07.02.006--Not Available
Extravasation08.01.03.008--Not Available
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hyporeflexia17.02.01.003--
Ileus07.13.01.001--
Ileus paralytic07.02.05.001--Not Available
Leukopenia01.02.02.001--Not Available
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