Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vinblastine
Drug ID BADD_D02358
Description Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Indications and Usage For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Marketing Status Prescription; Discontinued
ATC Code L01CA01
DrugBank ID DB00570
KEGG ID D08675
MeSH ID D014747
PubChem ID 13342
TTD Drug ID D0W9MM
NDC Product Code Not Available
Synonyms Vinblastine | Vincaleukoblastine | Lemblastine | Velban | Vinblastina Lilly | Velbe | Vinblastine Sulfate | Sulfate, Vinblastine | Vinblastinsulfat-Gry | Cellblastin | Vinblastin Hexal
Chemical Information
Molecular Formula C46H58N4O9
CAS Registry Number 865-21-4
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neuropathy peripheral17.09.03.003--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Pain08.01.08.004--
Pain in jaw15.02.01.003--Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Phlebitis12.02.01.002; 24.05.03.001--
Photophobia17.17.02.006; 06.01.01.004--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Haemorrhage24.07.01.002--Not Available
Ischaemia24.04.02.004--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
Bone marrow failure01.03.03.005--
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