Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone hydrochloride
Drug ID BADD_D02356
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Marketing Status Prescription
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09699
MeSH ID D000069503
PubChem ID 6918313
TTD Drug ID D0X6BV
NDC Product Code 55154-4627; 55154-4624; 0456-1110; 50370-0035; 0456-1120; 0456-1140; 55111-955; 0456-1141; 0456-1111; 65129-2248; 0456-1101; 0456-1100; 0456-1121; 66039-903; 65015-848; 65372-1203
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H28ClN5O2
CAS Registry Number 163521-08-2
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Angle closure glaucoma06.03.01.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Cataract06.06.01.001--
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Ejaculation delayed21.03.01.001--Not Available
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling jittery08.01.09.016--Not Available
Flatulence07.01.04.002--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.004--Not Available
Hallucination19.10.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypomania19.16.02.001--Not Available
Hyponatraemia14.05.04.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Libido decreased21.03.02.005; 19.08.03.001--
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