Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Urokinase
Drug ID BADD_D02320
Description Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase.[A191943] Urokinase remains connected between these 2 chains by a sulfhydryl bond.[A191943] Urokinase was granted FDA approval on 16 January 1978.[L12138]
Indications and Usage Urokinase can be used for the treatment of pulminary embolism, coronary artery thrombosis, IV catheter clearance, and venous and arterial blood clots.
Marketing Status Discontinued
ATC Code B01AD04
DrugBank ID DB00013
KEGG ID D03341
MeSH ID D014568
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Urokinase-Type Plasminogen Activator | Urokinase Type Plasminogen Activator | Plasminogen Activator, Urokinase-Type | U-Plasminogen Activator | U Plasminogen Activator | U-PA | Urinary Plasminogen Activator | Urokinase | Renokinase | Abbokinase | Kidney Plasminogen Activator | Single-Chain Urokinase-Type Plasminogen Activator | Single Chain Urokinase Type Plasminogen Activator
Chemical Information
Molecular Formula Not Available
CAS Registry Number 9039-53-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chromosomal abnormalities and abnormal gene carriersIntegrin alpha-VP06756T6710310397732; 10402467; 11360187; 11257120
Chromosomal abnormalities and abnormal gene carriersUrokinase plasminogen activator surface receptorQ03405T3614710397732; 10402467; 11360187; 11257120
Chromosomal abnormalities and abnormal gene carriersG-protein coupled estrogen receptor 1O08878Not Available10397732; 10402467; 11360187; 11257120
Chromosomal abnormalities and abnormal gene carriersTyrosine-protein kinase CSKP41240T0874110397732; 10402467; 11360187; 11257120
Diabetes mellitusMitogen-activated protein kinase 1P28482T5897010402467; 10591631; 11805108
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Back pain15.03.04.005--
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Haematocrit decreased13.01.05.001--Not Available
Hemiplegia17.01.04.002--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Mouth ulceration07.05.06.004--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Vomiting07.01.07.003--
Haemorrhage24.07.01.002--Not Available
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