Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tropicamide
Drug ID BADD_D02303
Description Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors.[A230103] Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures.[A229958] It is also used in combination with [hydroxyamphetamine] for the same indication.[L32178] Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.[A229958]
Indications and Usage Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
Marketing Status Prescription; Discontinued
ATC Code S01FA06
DrugBank ID DB00809
KEGG ID D00397
MeSH ID D014331
PubChem ID 5593
TTD Drug ID D09PNY
NDC Product Code 51552-1016; 52286-0010; 17478-101; 70518-2759; 70069-121; 0404-7192; 24208-585; 38779-0273; 61314-354; 73309-019; 24208-590; 0065-0355; 0998-0355; 62991-2940; 61314-355; 17478-102; 57419-0002; 51927-2670
Synonyms Tropicamide | N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide | N-Ethyl-N-(4-pyridylmethyl)tropamide | Minims Tropicamide | Mydriafair | Mydriaticum | Mydrum | Ocu-Tropic | Ocu Tropic | OcuTropic | Tropicacyl | Tropicamide Faure | Tropicamide Minims | Tropicamide Monofree | Tropicamide Monohydrochloride, (R)-Isomer | Tropicamide Monohydrochloride, (S)-Isomer | Tropicamide, (+-)-Isomer | Tropicamide, (R)-Isomer | Tropicamide, (S)-Isomer | Colircusi Tropicamida | Mydral
Chemical Information
Molecular Formula C17H20N2O2
CAS Registry Number 1508-75-4
SMILES CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.011010%
Intraocular pressure increased13.07.04.0020.011010%Not Available
Iridocyclitis06.04.03.0010.011010%Not Available
Keratitis06.04.02.002--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.011010%Not Available
Malaise08.01.01.0030.022019%
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Mydriasis06.05.03.004; 17.02.11.0030.016514%Not Available
Nausea07.01.07.0010.033029%
Nervous system disorder17.02.10.001--Not Available
Ocular hyperaemia06.04.05.0040.016514%Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Pain08.01.08.004--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.031--Not Available
Palpitations02.01.02.003--
Photophobia17.17.02.006; 06.01.01.0040.033029%
Pruritus23.03.12.001--
Pulse abnormal13.14.04.0040.011010%Not Available
Punctate keratitis06.04.02.003--Not Available
Rash erythematous23.03.06.003--Not Available
Respiratory arrest22.02.01.0090.011010%Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Salivary hypersecretion07.06.01.0090.011010%Not Available
Seizure17.12.03.0010.016514%
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.0030.011010%Not Available
Strangury20.02.02.017--Not Available
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