Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Trimethadione
Drug ID BADD_D02287
Description An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Indications and Usage Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Marketing Status approved
ATC Code N03AC02
DrugBank ID DB00347
KEGG ID D00392
MeSH ID D014293
PubChem ID 5576
TTD Drug ID D0U4VT
NDC Product Code Not Available
UNII R7GV3H6FQ4
Synonyms Trimethadione | Troxidone | Tridione | Trimetin
Chemical Information
Molecular Formula C6H9NO3
CAS Registry Number 127-48-0
SMILES CC1(C(=O)N(C(=O)O1)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability19.04.02.013; 08.01.03.011--
Leukopenia01.02.02.001--Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphoma16.20.01.001; 01.12.01.001--Not Available
Malaise08.01.01.003--
Muscular weakness17.05.03.005; 15.05.06.001--
Myasthenic syndrome16.32.01.002; 15.05.08.003; 10.04.05.005; 17.05.04.004--Not Available
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Neutropenia01.02.03.004--Not Available
Non-Hodgkin's lymphoma01.17.01.001; 16.35.01.001--Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Personality change19.05.01.006; 17.02.05.019--
Photophobia17.17.02.006; 06.01.01.004--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash morbilliform23.03.13.005--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.003--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Emotional distress19.04.02.008--Not Available
Lupus-like syndrome23.03.02.004; 15.06.02.004; 10.04.03.003--Not Available
Haemorrhage24.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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