| ADR Ontology |
| ADR Term |
Myasthenic syndrome |
| ADR ID |
BADD_A02914 |
| ADR Hierarchy |
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| Description |
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) [MeSH] |
| MedDRA Code |
10028424 |
| MeSH ID |
D015624
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
Not Available
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| Synonym |
| Eaton-Lambert syndrome | Myasthenia gravis-like paralysis | Myasthenia gravis-like reaction | Myasthenia gravis-like syndrome | Myasthenic syndrome | Myasthenic syndromes in diseases classified elsewhere | Reaction myasthenia gravis-like | Drug-induced myasthenic syndrome | Lambert-Eaton myasthenic syndrome | Lambert-Eaton Myasthenic Syndrome | Lambert Eaton Myasthenic Syndrome | Eaton-Lambert Myasthenic Syndrome | Eaton Lambert Myasthenic Syndrome | Myasthenic Syndrome, Eaton-Lambert | Syndrome, Eaton-Lambert Myasthenic | Myasthenic Syndrome, Lambert-Eaton | Myasthenic Syndrome, Lambert Eaton | Syndrome, Lambert-Eaton Myasthenic | Myopathic-Myasthenic Syndrome of Lambert-Eaton | Lambert-Eaton Myopathic-Myasthenic Syndrome | Lambert-Eaton Myopathic-Myasthenic Syndromes | Lambert-Eaton Syndrome | Lambert Eaton Syndrome | Syndrome, Lambert-Eaton | Myasthenic-Myopathic Syndrome of Lambert-Eaton | Lambert-Eaton Myasthenic-Myopathic Syndrome | Lambert-Eaton Myasthenic-Myopathic Syndromes | Myasthenic Myopathic Syndrome of Lambert Eaton | Myopathic-Myasthenic Syndrome of Eaton-Lambert | Eaton-Lambert Myopathic-Myasthenic Syndrome | Eaton-Lambert Myopathic-Myasthenic Syndromes | Myopathic Myasthenic Syndrome of Eaton Lambert | Eaton-Lambert Syndrome | Eaton Lambert Syndrome | Syndrome, Eaton-Lambert | Myasthenic-Myopathic Syndrome of Eaton-Lambert | Eaton-Lambert Myasthenic-Myopathic Syndrome | Myasthenic Myopathic Syndrome of Eaton Lambert |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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