Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bacteraemia11.01.11.0010.003153%
Blister23.03.01.001; 12.01.06.002--Not Available
Blood creatinine increased13.13.01.004--
Blood culture positive13.08.02.0020.000556%Not Available
Blood glucose decreased13.02.02.0010.000556%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood magnesium decreased13.11.01.0080.000556%Not Available
Blood potassium decreased13.11.01.0100.002040%Not Available
Blood potassium increased13.11.01.0110.001113%Not Available
Blood pressure abnormal13.14.03.0010.000742%Not Available
Blood pressure decreased13.14.03.0020.005750%Not Available
Blood pressure diastolic decreased13.14.03.0030.000371%Not Available
Blood pressure fluctuation24.06.01.0020.000556%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood sodium decreased13.11.01.0120.001669%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.0010.000556%Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Brain abscess17.06.07.001; 11.01.03.0030.000371%Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.0010.003524%
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block right02.03.01.0110.000371%Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Carbon dioxide increased13.02.01.0110.000742%Not Available
Cardiac arrest02.03.04.0010.001984%
Cardiac failure02.05.01.0010.002662%
Cardiac failure congestive02.05.01.0020.008347%Not Available
Cardiac failure high output02.05.01.0100.000556%Not Available
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