Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tolvaptan
Drug ID BADD_D02246
Description Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Indications and Usage Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis.
Marketing Status Prescription; Discontinued
ATC Code C03XA01
DrugBank ID DB06212
KEGG ID D01213
MeSH ID D000077602
PubChem ID 216237
TTD Drug ID D03KZM
NDC Product Code 46602-0027; 46602-0028; 14501-0066; 67877-637; 60505-4705; 49884-768; 59148-020; 31722-869; 46602-0031; 59148-083; 60505-4704; 49884-770; 59148-082; 59148-089; 14501-0085; 46602-0029; 59148-087; 59148-079; 65977-0100; 60862-008; 46602-0030; 59148-021; 59148-080; 57884-0027; 59148-088; 67877-636
Synonyms Tolvaptan | 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine | Samsca | OPC 41061 | OPC-41061 | OPC41061
Chemical Information
Molecular Formula C26H25ClN2O3
CAS Registry Number 150683-30-0
SMILES CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
White blood cell count decreased13.01.06.012--
Mental status changes19.07.01.0010.000422%Not Available
Tubulointerstitial nephritis20.05.02.0020.000281%Not Available
Intracardiac thrombus24.01.05.003; 02.01.01.007--Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Brain oedema17.07.02.003; 12.01.10.0100.000147%
Upper respiratory tract inflammation22.02.05.0180.000281%Not Available
Urethral haemorrhage24.07.03.006; 20.07.01.003--Not Available
Lung cancer metastatic22.08.01.004; 16.19.02.0030.000147%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Malignant neoplasm progression16.16.01.005--Not Available
Lymphatic disorder01.09.01.003--Not Available
Protein urine present13.13.02.0060.000281%Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.000422%Not Available
Transaminases increased13.03.01.015--Not Available
Cerebral disorder17.02.10.0170.000281%Not Available
Fluid intake reduced14.05.10.0010.000422%Not Available
Infected cyst16.02.02.003; 11.01.08.0210.000281%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000220%Not Available
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.0040.001547%
Drug resistance08.06.01.0050.000073%Not Available
Urine output decreased13.13.03.0010.000422%
Urine output increased13.13.03.0020.000844%Not Available
Hepatic enzyme increased13.03.01.0190.001266%Not Available
Neurological symptom17.02.05.010--Not Available
The 9th Page    First    Pre   9 10 11    Next   Last    Total 11 Pages