Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tolvaptan
Drug ID BADD_D02246
Description Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Indications and Usage Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis.
Marketing Status Prescription; Discontinued
ATC Code C03XA01
DrugBank ID DB06212
KEGG ID D01213
MeSH ID D000077602
PubChem ID 216237
TTD Drug ID D03KZM
NDC Product Code 46602-0027; 46602-0028; 14501-0066; 67877-637; 60505-4705; 49884-768; 59148-020; 31722-869; 46602-0031; 59148-083; 60505-4704; 49884-770; 59148-082; 59148-089; 14501-0085; 46602-0029; 59148-087; 59148-079; 65977-0100; 60862-008; 46602-0030; 59148-021; 59148-080; 57884-0027; 59148-088; 67877-636
Synonyms Tolvaptan | 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine | Samsca | OPC 41061 | OPC-41061 | OPC41061
Chemical Information
Molecular Formula C26H25ClN2O3
CAS Registry Number 150683-30-0
SMILES CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood creatinine increased13.13.01.0040.005485%
Blood glucose decreased13.02.02.0010.000844%Not Available
Blood glucose increased13.02.02.0020.000844%Not Available
Blood potassium decreased13.11.01.0100.000844%Not Available
Blood potassium increased13.11.01.0110.000703%Not Available
Blood pressure abnormal13.14.03.0010.000281%Not Available
Blood pressure decreased13.14.03.0020.001406%Not Available
Blood pressure fluctuation24.06.01.0020.000281%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood sodium abnormal13.11.01.0250.000422%Not Available
Blood sodium decreased13.11.01.0120.009423%Not Available
Blood sodium increased13.11.01.0130.004641%Not Available
Blood urea increased13.13.01.0060.003657%Not Available
Blood uric acid increased13.02.04.0010.000844%Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.0010.000563%
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.001688%
Cardiac failure acute02.05.01.0050.000281%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000183%Not Available
Cardiomegaly02.04.02.0010.000073%Not Available
Cataract06.06.01.0010.000281%
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.001406%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholecystitis09.03.01.0010.000422%
Chronic obstructive pulmonary disease22.03.01.0070.000110%Not Available
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