Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tirofiban hydrochloride
Drug ID BADD_D02229
Description Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Indications and Usage For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
Marketing Status Prescription; Discontinued
ATC Code B01AC17
DrugBank ID DB00775
KEGG ID D01029
MeSH ID D000077466
PubChem ID 60946
TTD Drug ID D0BN9X
NDC Product Code 69787-025; 46439-8750; 13612-0009; 82169-025
Synonyms Tirofiban | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | Aggrastat | Agrastat | MK 383 | MK-383 | L 700462 | L-700462 | L-700,462 | L 700,462 | L700,462 | Tirofiban Hydrochloride | Tirofiban Hydrochloride Monohydrate
Chemical Information
Molecular Formula C22H39ClN2O6S
CAS Registry Number 150915-40-5
SMILES CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresIntegrin beta-3P05106T26457Not Available
Surgical and medical proceduresIntegrin alpha-IIbP08514Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac tamponade02.06.01.001--
Chills15.05.03.016; 08.01.09.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Extradural haematoma12.01.10.002; 24.07.04.002; 17.08.05.001--Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematocrit decreased13.01.05.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Headache17.14.01.001--
Hypercholesterolaemia14.08.01.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Pericardial haemorrhage24.07.01.013; 02.06.01.003--Not Available
Platelet count decreased13.01.04.001--
Presyncope02.01.02.007; 24.06.02.010; 17.02.05.009--
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