Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coronary artery stenosis02.02.01.010; 24.04.04.0170.008811%Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.0070.002627%Not Available
Cough22.02.03.0010.016363%
Creatinine renal clearance increased13.13.01.0150.001259%Not Available
Crying12.02.11.001; 08.01.03.005; 19.04.02.002; 17.02.05.013--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.001259%
Cystitis haemorrhagic20.03.02.0030.001259%Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.0020.001259%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.001259%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.003776%Not Available
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.001259%Not Available
Discomfort08.01.08.0030.006293%Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disseminated intravascular coagulation01.01.02.002; 24.01.01.0100.000657%
Disturbance in attention19.21.02.002; 17.03.03.001--
Diverticulitis11.01.07.003; 07.10.02.0010.004405%Not Available
Diverticulum07.10.01.0010.001259%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Duodenal ulcer07.04.02.0020.001888%
Duodenal ulcer haemorrhage24.07.02.020; 07.04.02.004--Not Available
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