Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.052865%Not Available
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.002517%Not Available
Acute respiratory distress syndrome22.01.03.0010.001149%
Ageusia17.02.07.001; 07.14.03.0030.001888%Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Alveolar proteinosis22.01.02.0090.001149%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anger19.04.02.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.016363%
Angina unstable24.04.04.004; 02.02.02.0040.019510%Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Aortic dissection24.02.03.0020.001888%Not Available
Aphasia17.02.03.001; 19.21.01.001--
Appendicitis11.01.07.001; 07.19.01.0010.002517%
Arrhythmia02.03.02.001--Not Available
Arterial thrombosis24.01.01.0020.001888%Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000328%Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.001259%Not Available
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