Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiagabine hydrochloride
Drug ID BADD_D02211
Description Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Indications and Usage For the treatment of partial seizures
Marketing Status Prescription; Discontinued
ATC Code N03AG06
DrugBank ID DB00906
KEGG ID D02097
MeSH ID D000078308
PubChem ID 91274
TTD Drug ID D0ED7U
NDC Product Code 63459-412; 0093-5031; 63459-404; 16714-154; 63459-402; 63459-416; 0093-8072; 69766-061; 72205-087; 29902-0004; 16714-153; 62756-224; 0093-5030; 62756-200; 72205-084; 16714-152; 72205-086; 72205-085; 16714-151; 0093-8076
Synonyms Tiagabine | N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid | Gabitril | NO 329 | NO-329 | Tiagabine Hydrochloride | (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride | Tiagabine, (S)-isomer | NO 328 | NO-328
Chemical Information
Molecular Formula C20H26ClNO2S2
CAS Registry Number 145821-59-6
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypokinesia17.01.02.009--Not Available
Hyponatraemia14.05.04.002--
Hyporeflexia17.02.01.003--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.001--
Hypotonia17.05.02.002; 15.05.04.008--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza11.05.03.001; 22.07.02.001--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Keratitis06.04.02.002--
Laryngitis22.07.03.001; 11.01.13.001--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased21.03.02.007; 19.08.03.002--
Liver function test abnormal13.03.01.013--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 8 Pages