Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thiothixene
Drug ID BADD_D02204
Description A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Indications and Usage For the management of schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AF04
DrugBank ID DB01623
KEGG ID D00374
MeSH ID D013888
PubChem ID 5454
TTD Drug ID D0E0LQ
NDC Product Code 60219-1675; 58159-042; 60219-1676; 53808-1129; 70518-1703; 51407-278; 70518-2544; 51079-589; 60219-1673; 0378-5010; 51407-276; 70954-015; 70518-3147; 60219-1674; 70518-2340; 70518-2594; 51407-277; 0378-2002; 0378-1001; 0378-3005; 70954-014; 51407-275; 70954-017; 48954-575; 70954-016; 51079-588
Synonyms Thiothixene | Tiotixene | Navane
Chemical Information
Molecular Formula C23H29N3O2S2
CAS Registry Number 5591-45-7
SMILES CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ParkinsonismNADH-ubiquinone oxidoreductase chain 1P03886Not Available8098932; 9309697
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Asphyxia22.02.02.001; 12.01.08.011--Not Available
Asthenia08.01.01.001--Not Available
Breast enlargement21.05.04.001--Not Available
Cardiac arrest02.03.04.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Fatigue08.01.01.002--
Glycosuria20.02.01.005--
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemolytic anaemia01.06.03.002--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
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