Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thioridazine hydrochloride
Drug ID BADD_D02201
Description A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
Indications and Usage For the treatment of schizophrenia and generalized anxiety disorder.
Marketing Status Discontinued; Prescription
ATC Code N05AC02
DrugBank ID DB00679
KEGG ID D00798
MeSH ID D013881
PubChem ID 66062
TTD Drug ID D0U1OE
NDC Product Code 61876-0075; 53489-500; 0378-0616; 0378-0618; 70518-1706; 53489-148; 51079-565; 46204-0006; 51079-567; 51927-1928; 51079-580; 0378-0612; 53489-150; 51079-566; 0378-0614; 53489-149
Synonyms Thioridazine | Thioridazine Hydrochloride | Thioridazine HCL | Thioridazine-Neurazpharm | Thioridazine Neurazpharm | ThioridazineNeurazpharm | Thiozine | Aldazine | Meleril | Mellaril | Melleril | Melleryl | Melleretten | Melzine | Rideril | Sonapax | Apo-Thioridazine | Apo Thioridazine | ApoThioridazine
Chemical Information
Molecular Formula C21H27ClN2S2
CAS Registry Number 130-61-0
SMILES CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)G protein-activated inward rectifier potassium channel 1P48549T38012Not Available
Sinus tachycardiaG protein-activated inward rectifier potassium channel 1P48549T38012Not Available
Tardive dyskinesiaD(2) dopamine receptorP14416T67162Not Available
Tardive dyskinesiaD(3) dopamine receptorP35462T02551Not Available
Tardive dyskinesiaD(4) dopamine receptorP21917T24983Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Headache17.14.01.001--
Hyperpyrexia08.05.02.002--Not Available
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Incontinence20.02.02.004; 17.05.01.006; 07.01.06.011--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Laryngeal oedema10.01.05.003; 23.04.01.005; 22.04.02.001--
Lethargy19.04.04.004; 08.01.01.008; 17.02.04.003--
Leukopenia01.02.02.001--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
Miosis06.05.03.003; 17.02.11.002--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Opisthotonus17.01.03.005--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pancytopenia01.03.03.003--Not Available
Parkinsonism17.01.05.003--Not Available
Parotid gland enlargement07.06.03.001--Not Available
Photosensitivity reaction23.03.09.003--
Pregnancy test false positive13.10.05.003--Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Restlessness17.02.05.021; 19.11.02.002--
Somnolence19.02.05.003; 17.02.04.006--
Sudden death08.04.01.003; 02.03.04.013--
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