Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thiabendazole
Drug ID BADD_D02196
Description 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Indications and Usage For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Marketing Status Discontinued
ATC Code D01AC06; P02CA02
DrugBank ID DB00730
KEGG ID D00372
MeSH ID D013827
PubChem ID 5430
TTD Drug ID D08QCJ
NDC Product Code 59014-0050; 49452-7723; 68022-7046; 51927-2278
Synonyms Thiabendazole | Tiabendazol | Thibendole | 2-(4'-Thiazolyl)Benzimidazole | Mintezol | Omnizole | Mintesol
Chemical Information
Molecular Formula C10H7N3S
CAS Registry Number 148-79-8
SMILES C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Irritability08.01.03.011; 19.04.02.013--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Lymphadenopathy01.09.01.002--Not Available
Mucous membrane disorder08.01.06.004--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Sjogren's syndrome15.06.01.015; 10.04.04.009; 07.06.01.010; 06.08.02.011--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Tinnitus17.04.07.004; 04.04.01.002--
Vision blurred06.02.06.007; 17.17.01.010--
Visual acuity reduced17.17.01.011; 06.02.03.001--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Xanthopsia06.02.05.002--Not Available
Conjunctival hyperaemia06.04.01.004--Not Available
Urine odour abnormal20.02.01.020--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Liver injury12.01.02.003; 09.01.07.022--Not Available
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