Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thalidomide
Drug ID BADD_D02192
Description A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
Indications and Usage For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
Marketing Status Prescription
ATC Code L04AX02
DrugBank ID DB01041
KEGG ID D00754
MeSH ID D013792
PubChem ID 5426
TTD Drug ID D0U7GK
NDC Product Code 59572-205; 59572-210; 59572-220; 59572-215; 69988-0052; 63818-0424; 17337-0301; 68554-0011
Synonyms Thalidomide | Sedoval | Thalomid
Chemical Information
Molecular Formula C13H10N2O4
CAS Registry Number 50-35-1
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Deep vein thrombosisThrombomodulinP07204T0858315235749; 7878634
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal perforation07.04.04.001--Not Available
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingival disorder07.09.03.001--Not Available
Glioblastoma16.30.02.002; 17.20.02.0020.000302%Not Available
Glossitis07.14.01.0010.001158%Not Available
Glossodynia07.14.02.0010.001158%Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Graft versus host disease12.02.09.001; 10.02.01.0270.000302%Not Available
Granulocytopenia01.02.03.003--Not Available
Gynaecomastia05.05.02.003; 21.05.04.003--
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haematocrit decreased13.01.05.0010.001737%Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.0030.017949%Not Available
Haemolytic anaemia01.06.03.0020.001158%Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.004--Not Available
Hallucination19.10.02.002--
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.006369%Not Available
Heart rate increased13.14.04.002--Not Available
Hepatic cirrhosis09.01.04.0010.001057%Not Available
Hepatic encephalopathy09.01.03.006; 17.13.01.0030.001737%Not Available
Hepatic failure09.01.03.0020.000906%
Hepatitis09.01.07.004--Not Available
Hepatitis C11.05.06.004; 09.01.09.0050.001737%Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
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