Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone cypionate
Drug ID BADD_D02171
Description Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.
Indications and Usage Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.[L1153]
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB13943
KEGG ID D00957
MeSH ID C016131
PubChem ID 441404
TTD Drug ID Not Available
NDC Product Code 62756-016; 0574-0820; 69097-536; 76420-065; 46439-8736; 48087-0096; 0409-6562; 71205-289; 51927-2706; 0009-0086; 0143-9659; 50090-0330; 51552-0104; 0009-0417; 0009-0347; 0143-9726; 0591-4128; 0409-6557; 72833-678; 60870-0252; 69097-802; 50090-4147; 62991-3132; 0517-1830; 64025-0021; 62756-017; 0143-9005; 52536-625; 51927-0189; 65089-0049; 50090-4920; 0009-0027; 63629-8705; 0574-0827; 50090-4921; 69097-537; 43647-678; 63187-647; 0009-0085; 50090-4446; 38779-0164; 63275-9982; 63629-8706; 82393-114; 46204-0371; 49803-006; 62756-015; 49452-7660; 0395-8137; 22552-0010
Synonyms testosterone 17 beta-cypionate | testosterone cypionate | testosterone 17 beta-cyclopentanepropionate | testosterone 17 beta-cyclopentylpropionate | Depo-Testosterone | Depo-Testosterone Cypionate | deposteron | Duratest | Testa-C | Testex Elmu | Andronate | Depostomead
Chemical Information
Molecular Formula C27H40O3
CAS Registry Number 58-20-8
SMILES CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=CC(=O)CCC35C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Peliosis hepatis09.01.07.010--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Polycythaemia01.07.01.0010.002392%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.031571%Not Available
Pulmonary infarction24.04.09.001; 22.06.02.0020.002392%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.000957%
Pulmonary thrombosis22.06.02.003; 24.01.06.0020.000957%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal disorder20.01.02.0020.000957%Not Available
Respiratory arrest22.02.01.0090.000250%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Rhinitis11.01.13.004; 22.07.03.0060.001913%
Seborrhoea23.02.07.001--Not Available
Sensory loss17.02.07.0070.000957%Not Available
Sexual dysfunction21.03.02.003; 19.08.05.0020.001435%Not Available
Skin disorder23.03.03.007--Not Available
Skin reaction10.01.03.019; 23.03.03.0130.000957%Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.001913%
Sodium retention14.05.04.003--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 17.02.08.003; 19.19.02.0020.002870%Not Available
Stress19.06.02.0040.001435%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Testicular pain21.13.01.0050.000957%
Thrombophlebitis superficial24.01.02.0020.001913%
Thrombosis24.01.01.0060.019134%Not Available
Transient ischaemic attack24.04.06.005; 17.08.04.0010.008610%
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