Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone
Drug ID BADD_D02170
Description Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.[A187114,L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone was isolated from samples and also synthesized in 1935.[A186943]
Indications and Usage To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB00624
KEGG ID D00075
MeSH ID D013739
PubChem ID 6013
TTD Drug ID D06XMU
NDC Product Code 48087-0113; 69238-1013; 49452-7652; 66887-004; 63629-2125; 0591-2114; 63629-2124; 0832-1120; 65089-0050; 63629-8455; 16714-967; 0603-7831; 0591-2363; 42667-5511; 49884-418; 82393-113; 24979-078; 76420-684; 43598-304; 38779-2598; 66887-001; 44132-008; 0832-1121; 64025-0010; 22552-0009; 0023-5990; 0051-8462; 38779-0163; 60870-0251; 45802-754; 70492-002; 51927-1026; 0591-2924; 71589-013; 0591-2921; 0591-2926; 51552-0029; 62332-488; 16714-968; 0245-0872; 44132-006; 0245-0871; 45802-366; 49452-7657; 0591-2925; 0051-8425; 76420-687; 68382-362; 76420-686; 0591-3216; 60592-721; 24979-130; 12875-8248; 45802-610; 76003-1083; 38779-2936; 0009-0074; 49884-510; 68180-943; 43647-568; 0051-8450; 0802-8068; 71589-011; 62991-2150; 69097-363; 0023-5992; 0009-5020; 0591-3524; 69339-158; 43742-1242; 76420-685; 70700-112; 68180-941; 63481-183; 43742-1436; 43742-0677; 63629-2352; 76420-699; 51552-0564; 16714-969; 0591-3217; 45802-281; 62332-552
Synonyms Testosterone | 17-beta-Hydroxy-4-Androsten-3-one | 17 beta Hydroxy 4 Androsten 3 one | Androtop | Histerone | Sterotate | Sustanon | Androderm | Testoderm | Testolin | Testopel | Testosterone Sulfate | AndroGel | 8-Isotestosterone | 8 Isotestosterone | 17-beta-Hydroxy-8 alpha-4-Androsten-3-one | 17 beta Hydroxy 8 alpha 4 Androsten 3 one | Andropatch | Testim
Chemical Information
Molecular Formula C19H28O2
CAS Registry Number 58-22-0
SMILES CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast cyst21.05.01.006; 16.14.01.004--Not Available
Breast enlargement21.05.04.001--Not Available
Breast induration21.05.05.010--Not Available
Breast mass21.05.04.0020.001188%Not Available
Breast pain21.05.05.003--
Breast tenderness21.05.05.0040.001781%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block right02.03.01.0110.000891%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.0010.006428%
Cardiac failure02.05.01.0010.003020%
Cardiac failure acute02.05.01.0050.001484%Not Available
Cardiac failure congestive02.05.01.0020.023157%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.002169%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.004750%Not Available
Cardiomegaly02.04.02.0010.000620%Not Available
Cardiomyopathy02.04.01.0010.007719%Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.0090.012159%Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.002078%Not Available
Carotid artery thrombosis17.08.01.025; 24.01.04.0070.000594%Not Available
Carpal tunnel syndrome17.09.02.0010.001188%Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebellar infarction24.04.06.007; 17.08.01.0130.003859%Not Available
Cerebral artery occlusion24.04.06.020; 17.08.01.0280.001484%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.012172%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.001484%
Cerebral thrombosis24.01.04.003; 17.08.01.0060.001188%Not Available
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