Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Terconazole
Drug ID BADD_D02164
Description Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a _triazole ketal derivative_.[A178096] Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels of safety, efficacy, and tolerability in clinical trials. [A178093]
Indications and Usage For the treatment of candidiasis (a yeast-like fungal infection) of the vulva and vagina.
Marketing Status Prescription; Discontinued
ATC Code G01AG02
DrugBank ID DB00251
KEGG ID D00888
MeSH ID C037815
PubChem ID 441383
TTD Drug ID D01AQT
NDC Product Code 53002-8130; 68071-1626; 0713-0552; 51672-1304; 22568-1125; 50090-0917; 0168-0347; 51672-1302; 45802-717; 53002-7240; 51672-1330; 50090-1196; 0168-0346; 63629-8837; 59349-0011
Synonyms terconazole | 1-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-4-(1-methylethyl)piperazine | Fungistat | R 42470 | Terazol | Gyno-Terazol
Chemical Information
Molecular Formula C26H31Cl2N5O3
CAS Registry Number 67915-31-5
SMILES CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Chills15.05.03.016; 08.01.09.001--
Dermatitis23.03.04.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dysmenorrhoea21.01.01.002--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Influenza like illness08.01.03.010--
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pain08.01.08.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Skin irritation23.03.04.009--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Musculoskeletal discomfort15.03.04.001--Not Available
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