Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir disoproxil
Drug ID BADD_D02155
Description Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Indications and Usage Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
Marketing Status Prescription
ATC Code J05AF07
DrugBank ID DB00300
KEGG ID D01982
MeSH ID D000068698
PubChem ID 5481350
TTD Drug ID D0D9HW
NDC Product Code 68554-0046
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C19H30N5O10P
CAS Registry Number 201341-05-1
SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Insulin resistance05.06.02.003; 14.06.02.003--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.026658%Not Available
Lactic acidosis14.01.01.0020.048872%Not Available
Laryngeal pain22.02.05.036--
Liver disorder09.01.08.0010.026658%Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.0130.008886%Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphoma16.20.01.001; 01.12.01.0010.002318%Not Available
Malaise08.01.01.003--
Malaria11.06.04.001; 01.03.02.0070.008886%Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Memory impairment19.20.01.003; 17.03.02.003--
Metabolic acidosis14.01.01.0030.031100%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Multiple fractures15.08.02.005; 12.04.02.0090.333220%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.0010.062201%
Myasthenia gravis10.04.05.001; 17.05.04.001; 15.05.08.0010.008886%
Myelopathy17.10.01.0070.008886%Not Available
Myopathy15.05.05.001--Not Available
Myositis15.05.01.0010.008886%
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
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